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. 2014 May 29;25(11):2526–2538. doi: 10.1681/ASN.2013080901

Figure 3.

Figure 3.

Improved glomerular function and injury in diabetic khk−/− mice compared to wild-type siblings. (A–D) Representative kidney sections stained with PAS in nondiabetic and diabetic wild-type mice and khk−/− mice. Glomerular area is shown. No significant glomerular hypertrophy was observed in any group. Original magnification, ×40 in A–D and G–J. (E) Quantification of glomerular area in all groups. (F) Quantification of mesangial area expansion in all groups. (G–J) Representative kidney sections stained for collagen IV in nondiabetic and diabetic wild-type and khk−/− mice. (K) Quantification of collagen IV–positive area in all groups. (L) Quantification of urinary albumin in all groups. (n=6). D, diabetic wild-type; ND, nondiabetic wild-type. Mean±SEM. *P<0.05 and **P<0.01 versus respective nondiabetic control; #P<0.05 and ##P<0.01.