Table 1.

Overall parameters in nondiabetic and diabetic (10 weeks) wild-type and khk−/− mice

Variable	Nondiabetic WT Mice	Nondiabetic khk−/− Mice	Diabetic WT Mice	Diabetic khk−/− Mice
Body weight (g)	35.02±1.11	32.36±0.85a	20.54±2.59b	26.38±0.48c,d
Blood glucose (mg/dl)	114±24	109±20	375±76b	359±90b
Hemoglobin A1c (%)	5.3±1.2	4.9±1.6a	9.2±0.6b	8.9±0.6b
Kidney weight/body weight ratio	0.009±0.006	0.008±0.001	0.028±0.002b	0.016±0.002e
BUN (mg/dl)	24.3±5.6	22.3±3.3	64.6±7.8b	34.3±6.3c,d,e
Serum creatinine (mg/dl)	0.24±0.09	0.22±0.03	0.54±0.07b	0.42±0.06b,e
Creatinine clearance (ml/min)	0.87±0.16	0.96±0.13	0.33±0.16b	0.78±0.12c
Triglycerides (mg/dl)	133±16	100±19	245±31b	160±26d,e
Cholesterol (mg/dl)	114±9.4	110±14.1	151±16.5e	114±10.2
Uric acid (mg/dl)	2.54±0.2	2.58±0.2	3.33±0.3b	2.86±0.1d

Values are expressed as mean±SD. WT, wild-type.

^aP<0.05 versus nondiabetic WT mice.

^bP<0.01 versus respective nondiabetic controls.

^cP<0.01 versus diabetic WT mice.

^dP<0.05 versus respective nondiabetic controls.

^eP<0.05 versus diabetic WT mice.