Table 3.

Relationships among diseases as defined by the Jaccard coefficient (defined as ratio of the number of shared pathways for a set of diseases to the number of all pathways for these diseases)

Disease Count	Diseases	Disease and Disease Group-Specific Pathways	Total Shared Pathways	Jaccard Coefficient
1	DN	Caveolar-mediated endocytosis signaling, crosstalk between dendritic cells and natural killer cells, leukocyte extravasation signaling, mitochondrial dysfunction, phospholipase C signaling, α-adrenergic signaling	31	1.00
1	MCD	Glioblastoma multiforme signaling	6	1.00
1	MGN	Xenobiotic metabolism signaling	6	1.00
2	IgAN, LN	Hepatic fibrosis hepatic stellate cell activation	15	0.65
2	DN, LN	Altered T cell and B cell signaling in rheumatoid arthritis, Cdc42 signaling, Fc-γ-receptor–mediated phagocytosis in macrophages and monocytes, neuroprotective role of THOP1 in Alzheimer's disease, Rac signaling	20	0.59
2	DN, IgAN	B cell development	14	0.41
3	DN, IgAN, LN	Allograft rejection signaling, autoimmune thyroid disease signaling, CD28 signaling in T-helper cells, complement system, graft-versus-host disease signaling, type 1 diabetes mellitus signaling, fMLP signaling in neutrophils, iCOS/iCOSL signaling in T-helper cells	13	0.38
2	DN, FSGS	Aryl hydrocarbon receptor signaling	5	0.16
2	DN, MCD	Virus entry through endocytic pathways	4	0.12
3	DN, FSGS, LN	Nur77 signaling in T lymphocytes	4	0.11
4	DN, FSGS, IgAN, LN	Antigen presentation pathway, dendritic cell maturation	3	0.09
4	DN, IgAN, LN, MGN	Calcium-induced T lymphocyte apoptosis, OX40 signaling pathway	3	0.09
3	DN, MCD, MGN	1433-mediated signaling	2	0.06
3	IgAN, LN, MCD	PI3K signaling in B lymphocytes	1	0.04
3	DN, LN, MCD	PXR/RXR activation	1	0.03
4	DN, HTN, MCD, MGN	NRF2-mediated oxidative stress response	1	0.03
5	DN, FSGS, IgAN, LN, MGN	Cytotoxic T lymphocyte-mediated apoptosis of target cells	1	0.03