Figure 2.

Diabetic nephropathy was improved in Mafb TG mice. (A) Urinary albumin, (B) BUN, and (C) serum creatinine were suppressed in TG STZ mice compared with WT STZ animals. (D) Periodic acid–Schiff-stained glomeruli. Glomerular hypertrophy and mesangial matrix expansion, which were observed in WT STZ mice, were ameliorated in TG STZ mice. Scale bar, 50 μm. (E) The mean glomerular surface area in TG STZ mice was smaller than that in WT STZ mice. (F) In the Masson’s trichrome staining, the blue area, which shows fibrosis, was smaller in TG STZ kidney compared with WT STZ kidney. Scale bar, 100 μm. (G) Tubulointerstitial injury index in TG STZ mice was ameliorated compared with WT STZ animals. Values represent the means±SEMs (n=7 mice per group). *P<0.05; **P<0.01.