Table 3.
Demographic, familial, clinical, and imaging predictors of rapid renal disease progression in ADPKD
| Predictor/Cohort Size (No. of Patients) | Type of Observational Study | Major Supporting Refs. |
|---|---|---|
| Sex | ||
| 1215 | Retrospective | 7 |
| 580 | Retrospective | 26 |
| 100 | Prospective | 40 |
| Race | ||
| 72 | Retrospective | 28 |
| Hyperfiltration in childhood | ||
| 180 | Retrospective | 32 |
| Gross hematuria | ||
| 1215 | Retrospective | 7 |
| 580 | Retrospective | 26 |
| 191 | Retrospective | 35 |
| 180 | Retrospective | 36 |
| 100 | Prospective | 40 |
| Pregnancy | ||
| 235 | Retrospective | 37 |
| Multiple UTIs | ||
| 256 | Retrospective | 39 |
| 180 | Retrospective | 36 |
| 94 | Retrospective | 38 |
| Cyst rupture | ||
| 100 | Prospective | 40 |
| Hypertension | ||
| 2085 | Retrospective | 70 |
| 1215 | Retrospective | 7 |
| 580 | Retrospective | 26 |
| 543 | Retrospective | 73 |
| 323 | Prospective | 48 |
| 235 | Retrospective | 37 |
| TKV | ||
| 312 | Prospective | 54 |
| 241 | Prospective | 4 |
| 229 | Prospective | 55 |
| RBF | ||
| 241 | Prospective | 58 |
| 59 |
P values for all studies were <0.01.