Table 1.
Histopathology associated with R. parkeri infection at 8 dpi
| Group | Vessel continuity disrupted |
Inflammation | Edema | Necrosis | Fibrinoid change |
Myodegeneration/ regeneration |
Endothelial necrosis |
Endothelial swelling |
|---|---|---|---|---|---|---|---|---|
| Control | − | 0 | 0 | 0 | − | − | − | − |
| Buffer | − | 0 | 0 | 0 | − | − | − | − |
| R. parkeri | − | 0 | 0 | 0 | − | − | − | − |
| Buffer + tick feeding | − | 2 | 1 | 1 | + | + | − | + |
| R. parkeri + tick feeding | + | 3 | 2 | 2 | + | + | + | + |
0, absence of the specified parameter; 1, mild histologic change (rare to infrequent presence as observed by high-powered magnification); 2, moderate histologic change (change is commonly observed in multiple high-powered fields or larger foci are present in selected areas); 3, marked histologic change (changes frequently observed in multiple high-powered fields or severe change in focal areas).