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. 2014 Oct 30;10(10):e1004746. doi: 10.1371/journal.pgen.1004746

Figure 7. COE function is required for differentiation and maintenance of diverse neuron types.

Figure 7

(A) coe is expressed in lineage-committed neoblasts (smedwi+) and early progeny [24], and diverse neuron types, including cholinergic (ChAT), GABAergic (gad), octopaminergic (tbh), dopaminergic (th), serotonergic (tph), and neuropeptidergic (cpp-1, npl, spp-18, spp-19, spp-2) neurons. Genes in green were identified in [24]. (B) To gain insights into how loss of COE function contributes to defects in nervous system differentiation, we analyzed the function of genes that were downregulated in coe(RNAi) animals. These analyses identified additional genes required for CNS regeneration (gbrb1, npl, scna-2, scna-3, pou4l-1) and patterning (nkx2l). In coe(RNAi) animals, we also detected upregulated genes enriched for GO terms associated with muscle development (Table 1), suggesting that COE may also function to repress the expression of mesoderm-specific genes.