Table 2. Candidate COE targets genes identified in S. mediterranea.

Gene Name	CNS function
Smed-gamma-aminobutyric acid receptor subunit gamma like (gbrg)	Neurotransmitter receptor
Smed-netrin-1	Axon Guidance
Smed-neural cell adhesion molecule-2 (ncam-2)	Cell adhesion
Smed-neuropeptide like-1 (npl-1)	Novel gene; Unknown
Smed-secreted peptide prohormone 18 (spp-18)	Neuropeptide
Smed-secreted peptide prohormone 19 (spp-19)	Neuropeptide
Smed-secreted peptide prohormone-2 (spp-2)	Neuropeptide
Smed-vesicle-associated membrane protein like-1 (vamp)	Cell adhesion
Smed-voltage-gated sodium channel (scna-1)	Ion Channel