Figure 11. The hearing loss of Spns2^tm1a/tm1a, Spns2^tm1b/tm1b and Spns2^tm1d/tm1d; Sox10-Cre mice showed a similar pattern of progression.

ABR thresholds of individual homozygotes (red), heterozygotes (blue) and wildtypes (green) are shown at 2, 3 and 14 or 4–10 weeks old. The control mice had immature thresholds at 2 weeks old and continued to mature to normal hearing levels at 3 weeks old. Spns2^tm1a/tm1a and Spns2^tm1d/tm1d; Sox10-Cre mice displayed progressive hearing loss from 2 to 3 weeks old. The red line in the middle bottom panel represents a control mouse homozygous for Spns2^tm1c but without carrying Sox10-Cre, and thus had no conditional knockout of Spns2 in the inner ear and normal hearing.