Figure 4. Thresholding on posterior probabilities provides a principled way to assess utility.

We demonstrate how utility curves are optimized by selecting SNPs that achieve a minimum posterior probability threshold at various benefit-to-cost ratios (R). The total number of SNPs selected at the maximum utility for R =  (1.25, 1.5, 2, 5, 10, 20) is (29.8, 39.2, 52.4, 119.1, 221.4, 405.4) which identifies approximately (29.8, 35.6, 43.4, 65.33, 79.9, 91.8) causal variants.