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. 2014 Oct 17;9:22. doi: 10.1186/1749-8104-9-22

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Copyright © 2014 Ceci et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Role of ErbB signaling in axonal regeneration. Three days post fertilization larvae were neurectomized (circles indicate position of neurectomy) after incubation with 0.05% of DMSO (controls) or 5 μM of AG1478 from 60 hpf to 5 dpf (48 hpn); this treatment does not affect Schwann cell survival but blocks ErbB signaling during the regeneration phase. Nerve regeneration in control (A-C) and drug treated larvae (D-F) was evaluated after 10 hpn, 14 hpn, and 48 hpn. The insets in C and F show the defasciculation of the regenerated nerve in treated larvae in comparison to controls. (G-I) Quantitative analysis of axonal extension after 10 hpn (G), 14 hpn (H), and 48 hpn (I) in control and AG1478 treated larvae. *P <0.05; ***P <0.001. (J) In 30% of ErbB inhibitor treated larvae, the non-neurectomized contralateral nerve appears defasciculated in comparison to the control nerve. Scale bar: C, F: 200 μm; A, B, D, E, J; insets in C and F: 100 μm.