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. 2014 May 6;592(Pt 14):3013–3030. doi: 10.1113/jphysiol.2014.271718

Figure 8. Effect of l-methionine on activation of TREK-1 channels.

Figure 8

A, l-methionine (1 mm) decreased the open probability of TREK-1 channels and arachidonic acid (10 μm) increased the open probability of the channels recorded in cell-attached mode at 0 mV in an asymmetrical K+ concentrations. Trace #2 is a continuous extension of trace #1. ‘C’ denotes the channel closed level, and dashed lines denote channel openings. B shows portions of traces #1 and #2 on an extended time scale. The amplitude histograms were obtained from 1 min of recordings at the baseline (C), after l-methionine (D) and after AA (E) each fitted with a Gaussian distribution function to obtain the current amplitude value for each histogram (dotted bell-shaped curves).