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. 2014 Oct 30;10(10):e1004751. doi: 10.1371/journal.pgen.1004751

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© 2014 Jung et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) N3-NEXT overexpression (second row) increased frequencies of verapamil-sensitive SP cell in MPSC1 and OVCAR3 cells compared with pLPC vector-transfected control (first row). Ectopic expression of WWP2 reduced SP fraction in both cell lines (third row). Co-expression of WWP2 in N3-NEXT-expressing cells reduced SP fraction (fourth row) as compared to cells with only N3-NEXT overexpression (second row). (B) Bar charts represent % of SP in each experimental condition.