Figure 2. Tumor growth and androgen levels in prostate cancer xenografts treated with castration and dutasteride.

Mean tumor volumes in mice bearing LuCaP35 (A) and LuCaP96 (B) xenografts. Intact male SCID mice were subcutaneously implanted with 30 mm³ pieces of the indicated xenograft. When tumors reached ∼300mm³, mice were castrated and randomly enrolled into cohorts treated with either vehicle (Cx) or dutasteride (Cx+Dut) for 8 weeks (denoted by black line above x-axis). Mean tumor volumes are depicted for each treatment group at the indicated days post enrollment (Cx, black squares; Cx+Dut, white circles).