Table 2.
The probability of early death and median overall survival in patients with CBF-AML diagnosed between 2000 and 2010 and aged 15-84 yrs. at diagnosis
| Early Death Rate | Overall Survival | Survival Rate (95% CI) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of patients | No. Early Events | P(Early death) | p-value | No. Events | †Median OS Months (95% CI) | p-value | 3 Months | 1 Year | 3 Year | 5 Year†† | |
| CBF-AML | 774 | 101 | 0.13 | - | 406 | 22 (19, 28) | - | 0.77 (0.74,0.80) | 61.5 (57.9,64.9) | 44.3 (40.5,48.1) | 35.7 (30.8,40.7) |
| CBF Type | |||||||||||
| inv(16) | 317 | 38 | 0.12 | 0.47 | 279 | NA | < 0.0001 | 0.81 (0.77,0.85) | 71.9 (66.4,76.6) | 57.3 (51.1,62.9) | 46.9 (38.4, 55.0) |
| t(8;21) | 457 | 63 | 0.14 | 127 | 16 (12, 18) | 0.75 (0.70,0.78) | 54.4 (49.6,59.0) | 35.5 (30.8,40.3) | 28.7 (22.8,34.8) | ||
| Gender | |||||||||||
| Male | 440 | 63 | 0.14 | 0.23 | 246 | 20 (17, 27) | 0.07 | 0.75 (0.71,0.79) | 59.7 (54.8,64.2) | 42.2 (37.2,47.1) | 34.2 (27.9,40.6) |
| Female | 334 | 38 | 0.11 | 160 | 25 (NA) | 0.80 (0.75,0.84) | 63.9 (58.3,69.0) | 47.2 (41.2,53.0) | 38.0 (30.1,45.9) | ||
| Race/Ethnicity | |||||||||||
| White | 529 | 78 | 0.15 | 0.19 | 291 | 21 (17, 24) | 0.003 | 0.74 (0.70,0.77) | 59.7 (55.3,63.9) | 42.1 (37.5,46.6) | 33.7 (27.9,39.6) |
| Black | 56 | 6 | 0.11 | 36 | 14 (8, 24) | 0.84 (0.71,0.91) | 54.3 (39.8,66.6) | 28.8 (15.9,43.1) | 17.4 (5.4,35.0) | ||
| Hispanic | 104 | 11 | 0.11 | 49 | 38 (NA) | 0.85 (0.76,0.90) | 66.6 (56.3, 75.0) | 50.8 (40.0,60.6) | 49.0 (34.7,61.8) | ||
| Other | 84 | 6 | 0.07 | 30 | NA | 0.87 (0.77,0.92) | 71.0 (59.7,79.8) | 60.2 (48.0,70.5) | 43.8 (26.5,60.1) | ||
| Age at DX | |||||||||||
| 15-44 yr. | 254 | 13 | 0.05 | <0.0001 | 74 | NA | < 0.0001 | 0.94 (0.90,0.96) | 82.8 (77.2,87.1) | 68.7 (61.8,74.5) | 55.2 (45.7,63.8) |
| 45-64 yr. | 283 | 28 | 0.10 | 153 | 22 (18, 36) | 0.79 (0.74,0.83) | 64.6 (58.6,70.0) | 43.9 (37.6,50.0) | 37.4 (29.2,45.6) | ||
| 65-74 yr. | 137 | 27 | 0.20 | 94 | 9 (6, 14) | 0.68 (0.59,0.75) | 42.3 (33.7,50.5) | 26.4 (18.6,34.8) | 16.4 (8.4,26.7) | ||
| 75-84 yr. | 100 | 33 | 0.33 | 85 | 2 (1, 4) | 0.44 (0.34,0.53) | 26.4 (18.0, 35.5) | 9.3 (4.0, 17.2) | 6.7 (1.7,16.4) | ||
| Year of DX | |||||||||||
| 2000-2002 | 157 | 18 | 0.12 | 0.42 | 110 | 16 (10, 19) | 0.002 | 0.75 (0.67,0.81) | 52.9 (44.8,60.3) | 32.5 (25.3,39.8) | 31.9 (24.7,39.2) |
| 2003-2005 | 198 | 32 | 0.16 | 123 | 21 (14, 38) | 0.74 (0.67,0.79) | 58.4 (51.2,64.9) | 43.5 (36.5,50.3) | 38.9 (32.1,45.7) | ||
| 2006-2008 | 251 | 33 | 0.13 | 130 | 25 (NA) | 0.78 (0.73,0.83) | 63.6 (57.3, 69.3) | 48.1 (41.7,54.2) | - | ||
| 2009-2010 | 168 | 18 | 0.11 | 43 | NA | 0.83 (0.76,0.88) | 73.0 (64.5,79.7) | - | - | ||
| Resident County | |||||||||||
| Metro | 687 | 88 | 0.13 | 0.58 | 360 | 22 (19, 28) | 0.74 | 0.78 (0.75,0.81) | 61.9 (58.0,65.5) | 44.5 (40.4, 48.5) | 36.7 (31.4,42.1) |
| Not Metro | 87 | 13 | 0.15 | 46 | 21 (NA) | 0.71 (0.60,0.79) | 58.5 (47.2,68.3) | 43.1 (31.6,54.1) | 28.6 (16.0,42.5) | ||
†
NA = not available due to number of events recorded
††
5 year survival only looked at those diagnosed in 2000-2005, n=355