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. 2014 Nov 1;25(21):3389–3400. doi: 10.1091/mbc.E14-06-1087

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© 2014 Ling et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 7: — A model for Osh4's role in regulating PI4P during secretion. Osh4 is recruited to the secretory vesicles through PI4P binding (and possibly through protein–protein interactions as well). Osh4 negatively regulates PI4P levels on the secretory vesicles and thereby enhances the Sec2–Sec15 interaction during this process. Finally, Osh4 leaves the secretory vesicles once PI4P levels are reduced below a certain threshold.