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. 2014 Oct 30;9(10):e112334. doi: 10.1371/journal.pone.0112334

Table 4. Adaptive mutations observed in the P2 and P3 regions of EV71:TLLm and EV71:TLLmv viral genomes.

EV71:BS vs EV71:TLLm6 EV71:BS vs EV71:TLLmv11
Amino acid changes Amino acid changes
Genome region Nucleotide changes Polyprotein7 Mature protein 8 Genome region Nucleotide changes Polyprotein Mature protein
2A G 3722 A G 992 E G 130 E 2A G 3722 A G 992 E G 130 E
2C A 4366 G T 1207 A T 96 A 2C A 4366 G T 1207 A T 96 A
3A C 5117 T A 1457 V A 17 V
3B T 5357 C L 1537 P L 11 P 3B T 5357 C L 1537 P L 11 P
3C A 5557 G I 1604 V I 56 V 3C A 5557 G I 1604 V I 56 V
A 5569 G I 1608 V I 60 V A 5569 G I 1608 V I 60 V
3D A 6211 G N 1822 D N 91 D 3D A 6070 T T 1775 S T 44 S9
T 6835 A S 2030 T S 299 T4 T 6137 C V 1797 A V 66 A3
A 7128 T R 2127 S R 396 S5 A 6211 G N 1822 D N 91 D
T 7247 C V 2167 A V 436 A5 C 6404 G S 1886 C S 155 C
T 6592 G W 1949 G W 218 G10
T 6835 A S 2030 T S 299 T4
A 7128 T R 2127 S R 396 S11
T 7247 C V 2167 A V 436 A5
6

Mutations are based on alignment with the reference EV71:BS genome.

7

Numbering of amino acids in the uncleaved polyprotein prior to maturation.

8

Numbering of amino acids in the mature protein.

9

Mutation located in the Ring finger domain of the RNA-dependent RNA Polymerase.

10

Mutation located in the Palm domain of the RNA-dependent RNA Polymerase.

11

Mutation located in the Thumb domain of the RNA-dependent RNA Polymerase.