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. 2014 Oct 30;10(10):e1004474. doi: 10.1371/journal.ppat.1004474

Figure 5. The effect of p12 mutant 6 on the immature Mo-MLV core.

Figure 5

(A and B) A mutation was introduced into the viral protease (PR) to inactivate its activity (D32L, called PR-). PR- (A) wild type and (B) p12 mutant 6 Mo-MLV VLPs were prepared for TEM and representative electron micrographs of each are shown. The coloured boxes show enlargements of individual virions. (C and D) Wild type and p12 mutant 6 Mo-MLV producer cells were pelleted and prepared for TEM. Representative electron micrographs of (C) wild type and (D) p12 mutant 6 immature VLPs budding from producer cells are shown. Immature VLPs are highlighted by the red boxes. All scale bars are 50 nm.