Skip to main content
. 2014 Oct 30;9(10):e110869. doi: 10.1371/journal.pone.0110869

Figure 1. Body weight.

Figure 1

Two-way ANOVA and Tukey contrasts were performed to test for differences among the groups. The high-fat diet, compared to the AIN93G diet, increased body weights; the difference was significant starting 4 weeks after the initiation of experimental feeding (p<0.01), and the significant increase continued throughout the experiment. Compared to wild-type mice, PAI-1 deficiency lowered body weights, and the difference was significant starting at week 6 of the experiment (p≤0.05). Values are means ± SEM (n = 11 per group for PAI-1−/− mice, n = 14 per group for wild-type mice; second cohort). AIN WT: AIN93G-fed wild-type mice, AIN PAI-1−/−: AIN93G-fed PAI-1−/− mice, HF WT: high-fat fed wild-type mice, HF PAI-1−/−: high-fat fed PAI-1−/− mice.