Fig. 1.

The glomerulosclerosis index (GSI; A), vascular damage score (B), and tubulointerstitial damage score (C) were elevated above SHAM in all groups with CKD and were unaffected by intervention. Representative glomeruli were classified using glomerulosclerosis scores [0 = normal glomerulus (a), +1 = <25% damage (b), +2 = 25–50% damage (c), +3 = 51–74% damage (d), and +4 = 75–100% damage (e)] based upon the degree of mesangial and basement membrane thickening and tuft collapse. Experimental infarction results are also shown in variable degrees of interstitial fibrosis and tubular dilatation, as well as marked vascular medial hypertrophy (arrowheads; f) in cortical vessels adjacent to affected glomeruli (bottom right). *P < 0.05 vs. SHAM; n = 8/group.