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. Author manuscript; available in PMC: 2014 Oct 30.
Published in final edited form as: Dev Cell. 2009 Mar;16(3):325–327. doi: 10.1016/j.devcel.2009.03.001

Figure 1. Working Models for Wnt Regulation of NMJ Formation.

Figure 1

(A) In zebrafish, prior to innervation, Wnt11r interacts with MuSK to activate Dvl-dependent pathways necessary for forming aneural clusters and guiding motor growth cones to the middle region of muscle fibers.

(B) In vitro studies suggest that Wnts regulate agrin-induced AChR clustering by binding to the receptor Frizzled (Fz). They may also act by interacting with MuSK. Differentiation of motor nerve terminals is regulated by a β-catenin-dependent pathway. Dashed lines indicate pathways to be determined.