Table 2.
Pathophysiologic parameters to be expected
| Parameter | Effect | Time from SAH |
|---|---|---|
| Physiological changes: | ||
| ICP | Increase | Seconds |
| MABP | Transient increase | Second |
| CBF | Fall | Seconds |
| CPP (MABP-ICP) | Fall followed by partial or complete recovery | Seconds |
| Mortality | Approximately 30% | 24 hr |
| Small vessel response: | ||
| Acute | Constriction | Minutes |
| Delayed | Not known | Not known |
| Large vessel response: | ||
| Acute | Constriction | Minutes |
| Delayed | Constriction | 24–48 hrs |
| Cell death: | ||
| Endothelium | Present | Minutes |
| Neuron | Present | Minutes |
| Neurological deficits | Present | Days |