Table 3. IC50 values for wild-type HIV for select antiretroviral agents [109, 110, 111].
Antiretroviral Drug | IC50 (mg/L) [109]* | |
---|---|---|
Zidovudine | 0.0053 | |
Lamivudine | 0.55 | |
Didanosine | 1.18 | |
Stavudine | 0.11 | |
Abacavir | 0.46 | |
Tenofovir | 0.20 | |
Nevirapine | 0.024 | |
Efavirenz | 0.00051 | |
Indinavir | 0.0037 | |
Nelfinavir | 0.0032 | |
Saquinavir | 0.0017 | |
Lopinavir | 0.0019 | |
Atazanavir [110] | No AAG: | 0.0049 |
With AAG: | 0.047 | |
Raltegravir [111] | 0.0036 |
From this reference except where otherwise specified.
AAG = α-1-acid glycoprotein, a drug-binding protein