Table 1.

Genotypic information for the obesity GRS calculation (Continued)

		GOLDN study						MESA study
Nearest Gene	Chr	SNP	Allele major/minor	Risk allele	β coefficient ± SEa	P-valueb	MAF	SNP	r2 (proxy SNP)	Allele major/minor	Risk allele	β coefficient ± SEa	P-valueb	MAF
CPEB4	5	rs6861681	G/A	G	0.2536 ± 0.2749	0.358	0.35	rs966544	1.000	A/G	G	0.1794 ± 0.1699	0.291	0.30
PCSK1	5	rs6234	C/G	C	0.3749 ± 0.3318	0.266	0.28	rs7713317	1.000	A/G	G	0.3190 ± 0.1773	0.072	0.28
ZNF608	5	rs4836133	A/C	A	0.1450 ± 0.2785	0.607	0.50	rs6864049	1.000	G/A	G	0.2153 ± 0.1535	0.161	0.46
FLJ35779	5	rs2112347	T/G	T	0.4647 ± 0.3149	0.147	0.37	rs3797580	1.000	T/C	T	0.0153 ± 0.1677	0.927	0.37
PCSK1	5	rs6232	A/G	G	0.9962 ± 0.7755	0.223	0.06	-	-	-	-	-	-	-
A1F1	6	rs2844479	T/G	T	0.1107 ± 0.3416	0.746	0.36	-	-	-	-	-	-	-
VEGFA	6	rs6905288	A/G	A	0.1332 ± 0.2542	0.601	0.43	rs6905288		A/G	A	0.1038 ± 0.1587	0.513	0.41
RSPO3	6	rs9491696	G/C	C	0.2345 ± 0.2805	0.409	0.49	rs9482771	1.000	C/G	G	0.1114 ± 0.1565	0.477	0.47
HMGA1	6	rs206936	A/G	G	0.2715 ± 0.3394	0.416	0.16	rs3798560	1.000	T/C	C	0.0661 ± 0.1959	0.736	0.21
PRL	6	rs4712652	A/G	G	0.3233 ± 0.3015	0.286	0.43	rs9366426	0.834	C/T	T	0.1372 ± 0.1579	0.385	0.45
LY86	6	rs1294421	G/T	G	0.3515 ± 0.2609	0.184	0.39	rs1294421	-	G/T	G	0.0287 ± 0.1630	0.860	0.39
TFAP2B	6	rs987237	A/G	G	0.7510 ± 0.3346	0.024	0.19	rs987237	-	A/G	G	0.0717 ± 0.2138	0.738	0.17
NFE2L3	7	rs1055144	G/A	A	0.6590 ± 0.4040	0.102	0.20	rs1055144	-	G/A	A	0.1140 ± 0.2100	0.587	0.17
TNKS	8	rs17150703	G/A	G	0.4493 ± 0.5057	0.372	0.10	rs17150703	-	G/A	A	0.2414 ± 0.2723	0.376	0.09
LRRN6C	9	rs10968576	A/G	G	0.1105 ± 0.2968	0.710	0.28	rs16912921	1.000	C/A	A	0.0750 ± 0.1700	0.659	0.31
PTER	10	rs10508503	C/T	C	1.1912 ± 0.4354	0.014	0.10	rs10508503	-	C/T	C	0.0291 ± 0.2653	0.913	0.10
BDNF	11	rs6265	G/A	G	0.2110 ± 0.3573	0.554	0.22	rs6265	-	G/A	G	0.1539 ± 0.1904	0.419	0.20
MTCH2	11	rs10838738	A/G	A	0.2473 ± 0.2919	0.406	0.37	rs4752856	1.000	G/A	A	0.0302 ± 0.1703	0.859	0.35
BDNF	11	rs925946	G/T	T	0.3625 ± 0.3343	0.283	0.30	rs7124442	1.000	T/C	C	0.1769 ± 0.1751	0.313	0.29
TUB	11	rs4929949	C/T	C	0.4956 ± 0.3032	0.111	0.50	rs9300092	0.966	A/G	G	0.0715 ± 0.1615	0.658	0.47
HOXC13	12	rs1443512	C/A	C	0.0772 ± 0.3090	0.803	0.23	rs1822438	0.947	C/A	C	0.0300 ± 0.1841	0.871	0.25
FA1M2	12	rs7138803	G/A	G	0.1046 ± 0.3640	0.774	0.40	rs7138803	-	G/A	A	0.3076 ± 0.1577	0.051	0.40
ITPR2/SSPN	12	rs718314	T/C	T	0.1407 ± 0.3603	0.697	0.26	rs10842708	1.000	A/G	G	0.0224 ± 0.1779	0.900	0.26

Abbreviations: Chr, chromosome; SNP; single nucleotide polymorphism; MAF, minor allele frequency.

^aEffect sizes in kg/m² for BMI obtained from the GOLDN population (n=782) and from MESA population (n=2035).

^bP-value indicates association between the SNP and BMI using generalized linear regression model for GOLDN (GENMOD procedure) adjusted by family relationships, gender, age and center; and general linear regression model for MESA studies adjusted by population structure, gender, age and center.