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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: J Acad Nutr Diet. 2014 May 1;114(12):1954–1966. doi: 10.1016/j.jand.2014.03.014

Table 3.

Dietary fat interactions with the obesity GRS for BMI (kg/m2) in GOLDN and MESA populations and in both populations meta-analyzed

GOLDN study (n=782)
MESA study (n=2035)
Meta-analysisa
Difference in BMI
 Difference in BMI
 Difference in BMI
β coefficient SE P for interactionb β coefficient SE P for interactionc β coefficient SE P for interaction Q
Total fats, % 0.0127 0.0046 0.010 0.0048 0.0024 0.046 0.0065 0.0057 0.002 0.128
SFAs, % 0.0325 0.0108 0.005 0.0126 0.0053 0.018 0.0165 0.0047 <0.001 0.098
MUFAs, % 0.0279 0.0120 0.021 0.0117 0.0059 0.047 0.0149 0.0053 0.005 0.226
PUFAs, % 0.0179 0.0136 0.194 0.0020 0.0100 0.845 0.0076 0.0081 0.347 0.346

Abbreviations: BMI, body mass index; SFA, saturated fatty acid; MUFA, monounsaturated fatty acid; PUFA, polyunsaturated fatty acid.

a

Estimated from the combined analyses using a weighted inverse normal method via the function “metagen”, with a fixed effect, using META R package; Q = Cochran‘s Q statistic.

b

Multivariate interaction model using SAS GENMOD procedure adjusted by familial relationships, gender, age, center, tobacco smoking (current vs. former/never), alcohol consumption (current vs. former/never), hyperlipidemia medication use, presence of diabetes, physical activity score and total energy intake.

c

General linear regression model adjusted by population structure, gender, age, center, tobacco smoking (current vs. former/never), alcohol consumption (current vs. former/never), hyperlipidemia medication use, presence of diabetes, physical activity and total energy intake.