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. Author manuscript; available in PMC: 2015 Apr 30.
Published in final edited form as: Nature. 2014 Aug 31;514(7524):633–637. doi: 10.1038/nature13637

Fig. 4. Prophage induction is limited by type III-A CRISPR immunity in tolerant lysogens.

Fig. 4

a, Plaque-forming potential (measured in pfu/ml) of supernatants from overnight cultures of ΦNM1 lysogens carrying the tolerant spacer 32T or 43T CRISPR plasmids, or the pGG3 non-targeting control (C). b, Growth curve of ΦNM1-ErmR lysogens or a non-lysogen control harboring the pGG3 or spacer 43T CRISPR plasmids as indicated, with or without the addition of the prophage-inducing agent mitomycin C (MMC) at the indicated timepoint (black arrow). Error bars: mean ± s.d. (n=3).