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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Pharm Res. 2014 May 22;31(11):3106–3119. doi: 10.1007/s11095-014-1403-6

Fig. 6.

Fig. 6

PC-3 tumor-bearing mice were injected i.v. with saline, saline liposome, CuCl2 at 3.5 mg/kg or LpCu at a dose of 3.5 or 7.0 mg/kg (n = 5 or 6) on Days 0, 4, and 8. Two independent experiments were conducted (N = 2), of which one representative result is shown. Tumors (a) and body weights (b) of animals were measured daily. By Day 12, the tumor volumes of LpCu 3.5 mg/kg and LpCu 7.0 mg/kg were 23% and 51% smaller respectively than control animals injected with saline; 2 out of 5 mice in the CuCl2 3.5 mg/kg group died by Day 3, and the remaining 3 mice in the group were euthanized on Day 4 due to severe signs of acute toxicities. Results presented are MEAN ± SEM (n = 3 for CuCl2 3.5 mg/kg group, n = 6 for all other groups); * p<0.05, **p<0.01.