Table 3.
Complete Blood Biochemistry and Hematology
| Saline | Saline liposome |
LpCu 3.5 mg/kg |
LpCu 7.0 mg/kg |
CuCl2 3.5 mg/kg |
|
|---|---|---|---|---|---|
| Biochemistry |
|||||
| AST (U/L) | 568 | 386 | 873 | 573 | 176 |
| ALT (U/L) | 110 | 252 | 140 | 87 | 86 |
| Cr (mg/dL) | 0.4 | 0.4 | 0.5 | 0.4 | 0.2 |
| Hematology |
|||||
| WBC (K/µL) | 23.2 ± 8.3 | 27.6 ± 6.0 | 20.0 ± 6.6 | 15.2 ± 4.9 | 10.6 ± 1.0 * |
| LYM (K/µL) | 6.2 ± 1.9 | 7.9 ± 2.4 | 8.9 ± 3.0 | 7.1 ± 2.8 | 4.4 ± 1.6 |
| MON (K/µL) | 1.3 ± 0.6 | 1.9 ± 0.4 | 1.1 ± 0.6 | 1.1 ± 0.3 | 0.5 ± 0.2 |
| GRA (K/µL) | 15.7 ± 7.3 | 17.7 ± 4.0 | 10.2 ± 3.3 | 7.1 ± 1.3 | 5.7 ± 0.3 * |
| RBC (M/µL) | 8.7 ± 1.5 | 9.0 ± 0.3 | 8.8 ± 0.4 | 9.2 ± 0.6 | 9.8 ± 1.3 |
| HGB (g/dL) | 14.0 ± 2.4 | 14.9 ± 0.7 | 14.1 ± 0.8 | 14.9 ± 0.7 | 15.7 ± 1.8 |
| HCT (%) | 43.2 ± 7.3 | 43.8 ± 1.8 | 45.9 ± 0.6 | 44.0 ± 2.5 | 46.7 ± 4.3 |
| MCV (fL) | 49.6 ± 4.2 | 48.6 ± 2.9 | 52.2 ± 2.7 | 48.2 ± 1.5 | 47.3 ± 2.1 |
| MCH (pg) | 16.0 ± 0.9 | 16.5 ± 0.9 | 16.0 ± 0.9 | 16.2 ± 0.5 | 15.8 ± 0.4 |
| MCHC (g/dL) | 32.4 ± 1.4 | 33.9 ± 1.4 | 30.7 ± 1.0 | 33.8 ± 0.8 | 33.4 ± 0.8 |
| PLT (K/µL) | 429 ± 99 | 464 ± 69 | 440 ± 133 | 546 ± 44 | 989 ± 148 * |
| MPV (fL) | 10.2 ± 2.1 | 7.0 ± 0.2 | 7.2 ± 0.3 | 9.1 ± 2.2 | 7.8 ± 0.6 |
| PCT (%) | 0.37 ± 0.04 | 0.32 ± 0.04 | 0.32 ± 0.09 | 0.38 ± 0.03 | 0.76 ± 0.17 * |
Abbreviations: AST, aspartate aminotransferase; ALT, alanine aminotransferase; Cr, creatinine; WBC, white blood cell (leukocyte); LYM, lymphocyte; MON, monocyte; GRA, granulocyte; RBC, red blood cell; HGB, hemoglobin; HCT, hematocrit; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; PLT, total platelet count; MPV, mean platelet volume; PCT, platelet hematocrit. Biochemistry was measured from pooled serum samples within the same group, hence no standard deviation is shown (for ELISA analysis of the same parameters with standard deviations, see supplemental information Table 1s); Hematology results are MEAN ± SD (n=3 for CuCl2 group and n=5 for other groups).
P < 0.05.