Table 4.
Pathological Changes and Severeness in Experimental Animals
| Saline | Saline liposome |
LpCu 3.5 mg/kg |
LpCu 7.0 mg/kg |
CuCl2 3.5 mg/kg * |
|
|---|---|---|---|---|---|
| Posterior synechia (eye) | − | − | + | +++ | − |
| Photoreceptor degeneration (eye) | − | − | + | ++ | − |
| Outer nuclear layer apoptosis (eye) | − | − | + | ++ | − |
| Renal tubular necrosis and dilation | − | − | − | ++++ | ++++ |
| Renal tubular proteinaceous fluid | − | − | − | +++ | ++++ |
| Renal hemorrhage | − | − | − | + | − |
*
Two out of five mice died spontaneously after one dose of CuCl2 3.5 mg/kg, and the rest three were euthanized immediately.
+ and −, degree / frequency of pathological changes; −, no pathological changes; +, mild; ++, moderate; +++, severe; ++++, extremely severe.