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The effect of histamine receptor antagonists on IL-6 production in histamine-stimulated nasal fibroblasts was determined by ELISA. Nasal fibroblasts were pretreated with antagonists for H1R (H1RA, fexofenadine), H2R (H2RA, ranitidine), H3R (H3RA clobenpropit), and H4R (H4RA, JNJ7777120) for 2 hours prior to histamine (100 µM) stimulation. Values are expressed as the means±SE of independent experiments. *P<0.05 vs control. †P<0.05 vs histamine alone.
