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. Author manuscript; available in PMC: 2014 Oct 31.
Published in final edited form as: Arthritis Rheumatol. 2014 Jan;66(1):101–106. doi: 10.1002/art.38213

Figure 1. ProCPB deficiency exacerbates OA in mice.

Figure 1

(A) Representative toluidine-blue-stained sections of the stifle joints of CPB-deficient (Cpb2−/−; backcrossed >9 generations to the C57BL/6J background) and wild-type C57BL/6J control mice (Cpb2+/+) surgically induced to develop OA by medial meniscectomy. Arrowheads indicate areas of total cartilage loss. Scale bar for the low (top) magnification images, 500 μm; scale bar for the high (bottom) magnification images, 200 μm. (B) Histologic quantification of cartilage degeneration, osteophyte formation, and synovitis in (A). Data represent the mean ± s.e.m; Cpb2−/−, n=4; Cpb2+/+, n=5). *P≤0.05 by Mann-Whitney test.