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. Author manuscript; available in PMC: 2014 Oct 31.
Published in final edited form as: Arthritis Rheumatol. 2014 Jan;66(1):101–106. doi: 10.1002/art.38213

Figure 2. Levels of proCPB correlate positively with levels of inflammatory mediators in OA synovial fluid.

Figure 2

(A) Heatmap display of inflammatory mediators whose levels differ significantly between OA synovial fluids from individuals with high levels of proCPB and those with low levels of proCPB (FDR<4.1%; Significance analysis of microarrays was used for identifying statistically significant differences). High- and low-proCPB groups were formed based on the mean proCPB level of all analyzed OA synovial fluids (64.8%). In the heatmap, blue represents a decrease relative to the mean value obtained in samples from OA patients, yellow no change, and red an increase. Cytokine and chemokine levels were measured with a multiplex bead-based immunoassay. ProCPB, C3a, and MAC were measured by ELISA. Heatmap columns represent individual OA patients, and rows represent individual inflammatory mediators. (B) Pearson’s correlation analysis of paired proCPB and MAC measurements in synovial fluid from each individual OA patient, with proCPB concentrations expressed as a percentage of that observed in normal pooled plasma. C3a, complement component 3a; MAC, membrane attack complex (C5b-9); IFNγ, interferon gamma; IL, interleukin; MIP-1β, macrophage inflammatory protein-1 beta.