Table 1.
Characteristics of studies included in the systematic review
| First author | Year | Country | Ethnicity | Genotyping method | Design | Total sample size | Osteoporosis | Control | SNPs | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1. | Wynne, F [72] | 2002 | Ireland | Irish | PCR-RFLP | Case-Control | 511 | 381 | 130 | Fok1 |
| 2. | Van Pottelbergh [73] | 2002 | Belgium | Belgium | PCR-RFLP | Case-Control | 408 | 271 | 137 | Fok1 |
| 3. | Tarner [74] | 2012 | Turkey | Turkish | PCR-RFLP | Case-Control | 229 | 183 | 46 | Fok1 |
| 4. | Jakubowska [75] | 2012 | Netherlands | Netherlands | PCR-RFLP | Case-Control | 455 | 161 | 294 | Fok1 |
| 5. | Kanan [76] | 2013 | Jordan | Jordanian | PCR-RFLP | Case-Control | 210 | 120 | 90 | Fok1 |
| 6. | Zhang [77] | 2006 | Chinese | Chinese | PCR-RFLP | Case-Control | 92 | 26 | 66 | Fok1 |
| 7. | Kim, J. G [78] | 2001 | Korea | Korean | PCR-RFLP | Cross-sectional | 229 | - | - | Fok1 |
| 8. | Deng, H. W [79] | 2002 | USA | Caucasian | PCR-RFLP | Cross-sectional | 630 | - | - | Fok1 |
| 9. | Lau, E. M. C [9] | 2002 | Chinese | Chinese | PCR-RFLP | Cross-sectional | 684 | - | - | Fok1 |
| 10. | Chen,H . Y [80] | 2002 | Taiwan | Taiwan | PCR-RFLP | Cross-sectional | 163 | - | - | Fok1 |
| 11. | Strandberg, S. [81] | 2003 | Sweden | Swedish | PCR-RFLP | Cross-sectional | 88 | - | - | Fok1 |
| 12. | Rabon-stith,K. M [82] | 2005 | USA | USA (Maryland) | PCR-RFLP | Cross-sectional | 206 | - | - | Fok1 |
| 13. | Cusack, S. [83] | 2006 | Denmark | Danish | PCR-RFLP | Cross-sectional | 224 | - | - | Fok1 |
| 14. | Terpstra [84] | 2006 | Netherlands | Netherlands | PCR-RFLP | Cross-sectional | 120 | - | - | Fok1 |
| 15. | Lau, H. H. L [85] | 2006 | Chinese | southern Chinese | PCR-RFLP | Cross-sectional | 674 | - | - | Fok1 |
| 16. | Falchetti, A. [86] | 2007 | Italy | Lampedusa (Italian) | PCR-RFLP | Cross-sectional | 424 | - | - | Fok1 |
| 17. | Han, X. [87] | 2009 | Chinese | Han | PCR-RFLP | Cross-sectional | 100 | - | - | Fok1 |
| 18. | Hosseinnejad [88] | 2009 | IRAN | IRAN | PCR-RFLP | Cross-sectional | 205 | - | - | Fok1 |
| 19. | Hosseinnejad [89] | 2009 | IRAN | IRAN | PCR-RFLP | Cross-sectional | 312 | - | - | Fok1 |
| 20. | Ozaydin [90] | 2010 | Turkey | Turkish | PCR-RFLP | Cross-sectional | 88 | - | - | Fok1 |
| 21. | Galbav [91] | 2010 | Slovakia | Slovak | PCR-RFLP | Cross-sectional | 121 | - | - | Fok1 |
| 22. | Perez, A. [92] | 2008 | Argentina | Cordoba | PCR-RFLP | Case-Control | 176 | 108 | 68 | Bsm1 |
| 23. | Fontova, R. [93] | 2000 | Spain | Spanish | PCR-RFLP | Case-Control | 156 | 105 | 51 | Bsm1 |
| 24. | Uysal, A, R. [94] | 2008 | Turkey | Turkish | PCR-RFLP | Case-Control | 246 | 100 | 146 | Bsm1 |
| 25. | Eckstein [95] | 2002 | Israeli | Jewish Israeli | PCR-RFLP | Case-Control | 324 | 86 | 238 | Bsm1 |
| 26. | Borjas-Fajardo. L [96] | 2003 | Spain | Spanish | PCR-RFLP | Case-Control | 133 | 78 | 55 | Bsm1 |
| 27. | DurusuTanriover, M. [97] | 2010 | Turkey | Turkish | PCR-RFLP | Case-Control | 100 | 50 | 50 | Bsm1 |
| 28. | Chen, J. [98] | 2003 | Chinese | Chinese | PCR-RFLP | Case-Control | 61 | 40 | 21 | Bsm1 |
| 29. | Tamulaitien [99] | 2012 | Lithuania | Lithuania | PCR-RFLP | Case-Control | 73 | 28 | 45 | Bsm1 |
| 30. | Nelson [100] | 2000 | USA | African-American | PCR-RFLP | Cross-sectional | 43 | - | - | Bsm1 |
| 31. | Sowinska [101] | 2000 | Poland | Polish | PCR-RFLP | Case-Control | 88 | 40 | 48 | Bsm1 |
| 32. | Chen,H.Y [102] | 2001 | Chinese | Chinese | PCR-RFLP | Cross-sectional | 171 | - | - | Bsm1 |
| 33. | Pollak, R. D [103] | 2001 | Israeli | Israelis | PCR-RFLP | Cross-sectional | 634 | - | - | Bsm1 |
| 34. | Kubota, M [104] | 2001 | Japan | Japanese | PCR-RFLP | Cross-sectional | 126 | - | - | Bsm1 |
| 35. | Laaksonen, M. [105] | 2002 | Finland | Finish | PCR-RFLP | Cross-sectional | 93 | - | - | Bsm1 |
| 36. | van der Sluis, I. M. [106] | 2003 | Netherlands | Caucasian | PCR-RFLP | Cross-sectional | 148 | - | - | Bsm1 |
| 37. | Grundberg [107] | 2003 | Sweden | Swedish | PCR-RFLP | Cross-sectional | 343 | - | - | Bsm1 |
| 38. | Kammerer, C. M. [108] | 2004 | Mexico | Mexican American | PCR-RFLP | Cross-sectional | 471 | - | - | Bsm1 |
| 39. | Seremak-Mrozikiewicz, A [132] | 2004 | Poland | Polish | PCR-RFLP | Cross-sectional | 34 | - | - | Bsm1 |
| 40. | Palomba, S. [110] | 2005 | Italy | Italian | PCR-RFLP | Cross-sectional | 1100 | - | - | Bsm1 |
| 41. | Dong, J. [111] | 2006 | Chinese | Han | PCR-RFLP | Cross-sectional | 90 | - | - | Bsm1 |
| 42. | Bernardes[112] | 2005 | Portugal | Portuguese | PCR-RFLP | Cross-sectional | 114 | - | - | Bsm1 |
| 43. | Mitra, S. [113] | 2006 | India | Indian | PCR-RFLP | Cross-sectional | 246 | - | - | Bsm1 |
| 44. | Bezerra [114] | 2008 | Brazil | Brazilian | PCR-RFLP | Cross-sectional | 40 | - | - | Bsm1 |
| 45. | Musumeci [115] | 2009 | Italy | Sicilian | PCR-RFLP | Cross-sectional | 360 | - | - | Bsm1 |
| 46. | Stathopoulou, M. G. [116] | 2011 | Greece | Greece | PCR-RFLP | Cross-sectional | 578 | - | - | Bsm1 |
| 47. | Pouresmaeili [117] | 2013 | IRAN | IRAN | PCR-RFLP | Cross-sectional | 146 | - | - | Bsm1 |
| 48. | Horst -Sikorska, W. [118] | 2007 | Poland | Polish | PCR-RFLP | Cross-sectional | 279 | - | - | Both |
| 49. | Gonzalez [119] | 2013 | Mexico | Mexican-Mestizo | TaqMan | Case-Control | 320 | 232 | 88 | Both |
| 50. | Kanan, R. M. [120] | 2008 | Jordan | Jordanian | PCR-RFLP | Case-Control | 230 | 150 | 80 | Both |
| 51. | Lisker, R [121] | 2003 | Mexico | Mexican | PCR-RFLP | Case-Control | 122 | 65 | 57 | Both |
| 52. | Mansour, L. [122] | 2010 | Egypt | Egyptian | PCR-RFLP | Case-Control | 70 | 50 | 20 | Both |
| 53. | Rogers [123] | 2000 | no indicated | no indicated | PCR-RFLP | Cross-sectional | 46 | Both | ||
| 54. | Lorentzon [124] | 2001 | Sweden | Caucasian | PCR-RFLP | Cross-sectional | 99 | - | - | Both |
| 55. | Zajíčková [125] | 2002 | Czech | Czech | PCR-RFLP | Cross-sectional | 114 | - | - | Both |
| 56. | Vidal, C. [126] | 2003 | Malta | Malta | PCR-RFLP | Cross-sectional | 104 | - | - | Both |
| 57. | Bandrés [127] | 2005 | Spain | Caucasian | PCR-RFLP | Cross-sectional | 177 | - | - | Both |
| 58. | Ivanova, J. [128] | 2006 | Bulgaria | Bulgarian | PCR-RFLP | Cross-sectional | 219 | - | - | Both |
| 59. | Macdonald, H. M [129] | 2006 | UK | Scotland | PCR-RFLP | Cross-sectional | 3100 | - | - | Both |
| 60. | Yavuz [130] | 2007 | Turkey | Turkish | PCR-RFLP | Case-Control | 206 | 381 | 130 | Both |
| 61. | Sanwalka [131] | 2013 | India | Indian | PCR-RFLP | Case-Control | 120 | 271 | 137 | Both |