Table 2.
Case-Crossover, Control-Crossover, and Exposure Time Trend Adjusted Estimates, Medicaid Analytic eXtracts, 2000–2006
| Monitoring Dates |
Case-Crossover |
Control-Crossovera |
Case-Time-Control |
||||
|---|---|---|---|---|---|---|---|
| Start | End | EOR | 95% CI | EOR | 95% CI | EOR | 95% CI |
| Valdecoxib (Outcome: Acute Myocardial Infarction) | |||||||
| November 1, 2001 | June 30, 2002 | MNC | 38.52 | 32.03, 46.31 | MNC | ||
| November 1, 2001 | September 30, 2002 | 12.00 | 4.33, 33.28 | 4.55 | 4.37, 4.74 | 2.64 | 0.95, 7.32 |
| November 1, 2001 | December 31, 2002 | 4.88 | 2.90, 8.23 | 2.65 | 2.59, 2.72 | 1.84 | 1.09, 3.10 |
| November 1, 2001 | March 31, 2003 | 3.32 | 2.22, 4.96 | 1.90 | 1.86, 1.94 | 1.75 | 1.17, 2.62 |
| November 1, 2001 | June 30, 2003 | 2.77 | 1.98, 3.86 | 1.69 | 1.66, 1.72 | 1.64 | 1.17, 2.29 |
| November 1, 2001 | September 30, 2003 | 2.65 | 1.95, 3.59 | 1.56 | 1.54, 1.58 | 1.70 | 1.25, 2.31 |
| November 1, 2001 | December 31, 2003 | 2.28 | 1.75, 2.98 | 1.53 | 1.51, 1.55 | 1.49 | 1.14, 1.95 |
| November 1, 2001 | March 31, 2004 | 1.96 | 1.55, 2.48 | 1.43 | 1.41, 1.45 | 1.37 | 1.08, 1.74 |
| November 1, 2001 | June 30, 2004 | 1.72 | 1.38, 2.13 | 1.40 | 1.38, 1.41 | 1.23 | 0.99, 1.52 |
| November 1, 2001 | September, 30, 2004 | 1.66 | 1.36, 2.04 | 1.37 | 1.36, 1.38 | 1.21 | 0.99, 1.49 |
| November 1, 2001 | December 31, 2004 | 1.62 | 1.34, 1.97 | 1.36 | 1.35, 1.38 | 1.19 | 0.98, 1.44 |
| November 1, 2001 | March 31, 2005 | 1.56 | 1.29, 1.88 | 1.27 | 1.26, 1.28 | 1.22 | 1.01, 1.48 |
| November 1, 2001 | June 30, 2005 | 1.47 | 1.22, 1.77 | 1.20 | 1.19, 1.21 | 1.23 | 1.02, 1.48 |
| November 1, 2001 | September 30, 2005 | 1.41 | 1.18, 1.69 | 1.16 | 1.15, 1.17 | 1.22 | 1.01, 1.46 |
| November 1, 2001 | December 31, 2005 | 1.41 | 1.18, 1.69 | 1.16 | 1.15, 1.17 | 1.22 | 1.01, 1.46 |
| Aripiprazole (Outcome: Acute Myocardial Infarction) | |||||||
| November 15, 2002 | June 30, 2003 | MNC | 5.31 | 4.92, 5.74 | MNC | ||
| November 15, 2002 | September 30, 2003 | 2.67 | 0.71, 10.05 | 3.14 | 3.00, 3.29 | 0.85 | 0.23, 3.20 |
| November 15, 2002 | December 31, 2003 | 3.29 | 1.41, 7.66 | 2.51 | 2.42, 2.60 | 1.31 | 0.56, 3.05 |
| November 15, 2002 | March 31, 2004 | 3.00 | 1.47, 6.14 | 2.19 | 2.12, 2.25 | 1.37 | 0.67, 2.81 |
| November 15, 2002 | June 30, 2004 | 3.33 | 1.75, 6.35 | 2.05 | 2.00, 2.10 | 1.63 | 0.85, 3.10 |
| November 15, 2002 | September 30, 2004 | 2.40 | 1.42, 4.04 | 2.02 | 1.98, 2.07 | 1.19 | 0.70, 2.00 |
| November 15, 2002 | December 31, 2004 | 2.52 | 1.56, 4.09 | 1.89 | 1.86, 1.93 | 1.33 | 0.82, 2.16 |
| November 15, 2002 | March 31, 2005 | 2.13 | 1.38, 3.29 | 1.84 | 1.80, 1.87 | 1.16 | 0.75, 1.79 |
| November 15, 2002 | June 30, 2005 | 2.33 | 1.55, 3.51 | 1.79 | 1.76, 1.82 | 1.30 | 0.87, 1.96 |
| November 15, 2002 | September 30, 2005 | 2.16 | 1.47, 3.17 | 1.74 | 1.71, 1.77 | 1.24 | 0.85, 1.83 |
| November 15, 2002 | December 31, 2005 | 2.09 | 1.46, 3.01 | 1.69 | 1.67, 1.72 | 1.24 | 0.86, 1.78 |
| November 15, 2002 | March 31, 2006 | 1.81 | 1.29, 2.54 | 1.64 | 1.62, 1.67 | 1.10 | 0.78, 1.55 |
| November 15, 2002 | June 30, 2006 | 1.80 | 1.30, 2.50 | 1.60 | 1.57, 1.62 | 1.13 | 0.81, 1.57 |
| November 15, 2002 | September 30, 2006 | 1.68 | 1.23, 2.28 | 1.55 | 1.52, 1.57 | 1.08 | 0.80, 1.47 |
| November 15, 2002 | December 31, 2006 | 1.54 | 1.15, 2.06 | 1.51 | 1.49, 1.53 | 1.02 | 0.76, 1.37 |
| Telithromycin (Outcome: Acute Hepatotoxicity) | |||||||
| April 1, 2004 | September 30, 2004 | MNC | MNC | MNC | |||
| April 1, 2004 | December 31, 2004 | MNC | 5.88 | 5.09, 6.80 | MNC | ||
| April 1, 2004 | March 31, 2005 | 12.00 | 1.56, 92.29 | 2.76 | 2.54, 3.00 | 4.35 | 0.56, 33.48 |
| April 1, 2004 | June 30, 2005 | 3.25 | 1.06, 9.97 | 1.75 | 1.65, 1.87 | 1.85 | 0.60, 5.69 |
| April 1, 2004 | September 30, 2005 | 1.86 | 0.74, 4.65 | 1.44 | 1.36, 1.53 | 1.29 | 0.51, 3.23 |
| April 1, 2004 | December 31, 2005 | 2.25 | 0.98, 5.17 | 1.47 | 1.40, 1.55 | 1.53 | 0.66, 3.52 |
| April 1, 2004 | March 31, 2006 | 1.90 | 0.88, 4.09 | 1.35 | 1.29, 1.41 | 1.41 | 0.65, 3.04 |
| April 1, 2004 | June 30, 2006 | 1.82 | 0.87, 3.79 | 1.21 | 1.16, 1.27 | 1.50 | 0.72, 3.13 |
| April 1, 2004 | September 30, 2006 | 1.82 | 0.87, 3.79 | 1.16 | 1.11, 1.21 | 1.56 | 0.75, 3.27 |
| April 1, 2004 | December 31, 2006 | 1.82 | 0.87, 3.79 | 1.18 | 1.13, 1.23 | 1.54 | 0.74, 3.22 |
Abbreviations: CI, confidence interval; EOR, exposure odds ratio; MNC, model did not converge.
a Matched on age, sex, and index date of matched case.