Figure 6.

Meta-analysis of 18 studies for pneumococcal serotype invasiveness in children before the widespread use of pediatric pneumococcal vaccines. Odds ratios (ORs) were determined by comparing the ratio of the number of invasive to carriage isolates expressing a serotype to the corresponding ratio expressing serotype 14 in each study (Supplementary Materials). A, The pooled odds ratios (ORs) with 95% confidence intervals (CIs) for the 30 most prevalent serotypes or serogroups identified in the meta-analysis, listed from highest to lowest ORs. B–E, Study-specific ORs and 95% CIs for serotypes representative of high (ST1; B), medium (ST9V [C]; ST6B [D]), and low (ST11A; E) invasiveness. Data are displayed according to the numbering of respective studies (1–18) in the table in the Supplementary Materials. Open circles represent studies with no data for that serotype.