Table 2.
Logistic Regression Analysis Comparing 325 Hemophiliac Human Immunodeficiency Virus–Exposed Seronegative Individuals (Cases) and 1305 Individuals From the 1958 Birth Cohort (Controls) for KIR Genes and Genotypic Combination of KIR and HLA
| Test | Cases, % (No.) | Controls, % (No.) | P Value | Adjusted OR (95% CI) |
|---|---|---|---|---|
| KIR2DL1 | 96.3 (313) | 96.9 (1264) | .48 | 1.37 (.57–3.27) |
| KIR2DL2 | 51.7 (168) | 50.1 (654) | .89 | 1.02 (.76–1.37) |
| KIR2DL3 | 88.6 (288) | 91.7 (1197) | .97 | 1.01 (.59–1.72) |
| KIR2DL5 | 53.2 (173) | 46.2 (603) | .27 | 1.18 (.88–1.59) |
| KIR2DP1 | 96.3 (313) | 96.9 (1264) | .48 | 1.37 (.57–3.27) |
| KIR2DS1 | 42.2 (137) | 36.3 (474) | .09 | 1.30 (.96–1.76) |
| KIR2DS2 | 52.6 (171) | 50.6 (660) | .78 | 1.04 (.78–1.40) |
| KIR2DS3 | 31.1 (101) | 24.7 (322) | .17 | 1.26 (.91–1.76) |
| KIR2DS4 | 35.4 (115) | 39.1 (511) | .84 | 0.97 (.71–1.32) |
| KIR2DS5 | 33.2 (108) | 29.7 (388) | .14 | 1.27 (.93–1.74) |
| KIR3DL1 | 96.0 (312) | 95.6 (1248) | .49 | 1.31 (.60–2.85) |
| KIR3DS1 | 41.8 (136) | 36.2 (473) | .07 | 1.32 (.98–1.79) |
| KIR3DS1_hmz | 4.0 (13) | 4.4 (57) | .49 | 0.76 (.35–1.66) |
| HLA-A*3/11 | 30.8 (100) | 35.6 (422) | .19 | 0.81 (.59–1.11) |
| HLA-A*3/11 + KIR2DS4 | 10.5 (34) | 14.7 (175) | .08 | 0.65 (.41–1.06) |
| HLA*Bw4 | 66.0 (210) | 60.5 (711) | .38 | 1.15 (.84–1.57) |
| HLA*Bw4 80I | 30.2 (96) | 21.9 (258) | .78 | 0.95 (.66–1.36) |
| HLA*Bw4 + KIR3DL1 | 63.2 (201) | 58.2 (684) | .31 | 1.17 (.86–1.60) |
| HLA*Bw4 80I + KIR3DS1 | 11.6 (37) | 7.7 (91) | .90 | 0.97 (.55–1.69) |
| HLA group C1 | 81.8 (265) | 88.7 (758) | .13 | 0.71 (.46–1.10) |
| HLA group C1 hmz + KIR2DL3 hmz | 16.4 (53) | 20.7 (177) | .05 | 0.65 (.43–.99) |
| HLA group C2 | 66.0 (214) | 56.0 (479) | .006 | 1.58 (1.14–2.20) |
| HLA group C2 hmz + KIR2DL3 hmz | 7.7 (25) | 5.6 (48) | .75 | 1.10 (.59–2.06) |
| HLA group C2 + KIR2DL1 | 63.6 (206) | 53.9 (461) | .002 | 1.68 (1.21–2.32) |
| HLA group C2 + KIR2DS1 | 26.9 (87) | 20.0 (171) | .03 | 1.51 (1.05–2.17) |
Only the functional KIR2DS4 allele was included. ORs were corrected for population stratification. An OR of >1 reflects protection against HIV infection, and an OR of <1 reflects susceptibility to HIV infection. None of the variables shown here reached the threshold of significance (P = .0006).
Abbreviations: CI, confidence interval; hmz, homozygous; OR, odd ratio.