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. 2014 Oct;6(10):1380–1387. doi: 10.3978/j.issn.2072-1439.2014.08.27

Table 2. The full names, code genes and functions of common tumor makers.

Name Full name Gene Function
β2M β2-microglobulin B2M The heavy chain of the major histocompatibility complex (MHC) class I
AFP α-fetoprotein AFP The fetal counterpart of serum albumin
AFU α-L-fucosidase FUCA1 and FUCA2 A enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids
CA125 Carbohydrate antigen 125 MUC16 A glycoprotein located in cell membrane
CA15-3 Carbohydrate antigen 15-3 MUC1 A glycoprotein located in cell membrane
CEA Carcinoembryonic antigen A group of CEACAs and PSGs A glycoprotein functioned as immunoglobulin and cell adhesion molecule
CT Calcitonin CALCA A hormone involved in the regulation of calcium and phosphorus
CYFRA21-1 Cytokeratin 19 fragments KRT19 Fragments of cytokeratins 19
FER Ferritin FTL and FTH1 An intracellular iron storage protein
HE4 Human epididymis protein 4 WFDC2 A protein possibly involved in sperm maturation
NSE Neuron-specific enolase ENO2 An isoenzyme of enolase involved in glycolysis and gluconeogenesis
PSA Prostate specific antigen KLK3 A protease present in seminal plasma
SCC Squamous cell carcinoma antigen SERPINB3 A member of the serine protease inhibitors