Table 2.
Baseline characteristics of cases and controls
| Case | Control | P-value | ||
|---|---|---|---|---|
| (N=132) | (N=132) | |||
| Offspring (vs Original) cohort† | 38 (28.8) | 38 (28.8) | 0.999 | |
| Age at cognitive assessment (years)† | 77.4±9.4 | 77.4±9.4 | 0.953 | |
| Women† | 71 (53.8) | 71 (53.8) | 0.999 | |
| Education | <High-school degree | 14 (10.6) | 10 (7.6) | 0.835 |
| High-school degree | 37 (28.0) | 38 (28.8) | ||
| Some college | 46 (34.9) | 50 (37.9) | ||
| ≥College degree | 35 (26.5) | 34 (25.8) | ||
| Current smokers | 27 (20.9) | 13 (9.9) | 0.014 | |
| Systolic blood pressure (mm Hg) | 146.3±21.9 | 139.4±19.4 | 0.007 | |
| Diastolic blood pressure (mm Hg) | 74.7±11.0 | 74.1±10.3 | 0.640 | |
| Hypertension treatment | 75 (57.7) | 74 (57.4) | 0.957 | |
| Prevalent diabetes | 30 (27.3) | 18 (15.4) | 0.028 | |
| Prevalent atrial fibrillation | 13 (9.9) | 8 (6.1) | 0.255 | |
| Prevalent cardiovascular disease | 43 (32.6) | 30 (22.7) | 0.074 | |
| Mild dementia at stroke | 7 (5.3) | 2 (1.5) | 0.172 | |
| Mild dementia at cognitive assessment | 20 (15.5) | 4 (3.0) | <0.001 | |
| MMSE score, median (25th, 75th percentile) | 28.0 (27, 29) | 28.0 (26, 29) | 0.110 | |
| Time difference between covariate assessment and date of stroke (years) |
2.90±4.91 | 3.08±4.92 | 0.758 | |
| ApoEε4 genotype | 21 (19.8) | 31 (26.1) | 0.268 | |
Values are n (%) or mean ± SD.
Abbreviations: MMSE=Mini-Mental State Examination; ApoE ε4=Apolipoprotein E ε4.
†Matching factor