Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Figure 1. Enhancer-promoter interactions. eRNA associating with Mediator may induce chromatin looping for enhancer-promoter contact, leading to transcriptional activation from the target promoter. Contact may be stabilized by cohesin. Disruption of either eRNA, Mediator or cohesin may lead to loss of contact and transcriptional deactivation.
