Table 1.
PhoP regulon promoter architecture.
| Group | Architecture | Gene | H-NS repression | H-NS binding | %AT | Homolog in E. coli K-12 |
|---|---|---|---|---|---|---|
| A |
|
mgtA | N | N | 45 | Y |
| slyB | N | N | 45 | Y | ||
| yrbL | N | N | 46 | Y | ||
| phoP | N | N | 48 | Y | ||
| pmrD | N | N | 52 | Y | ||
| orgB | N | Y | 55 | N | ||
| B |
|
rstA | N | Y | 47 | Y |
| ompX | N | N* | 48 | Y | ||
| C |
|
mgtC | N | Y | 50 | N |
| pipD | N | Y | 52 | N | ||
| pgtE | Y | Y | 54 | N† | ||
| pagC | N | Y | 57 | N | ||
| ugtL | Y | Y | 60 | N | ||
| pagK | N | Y | 63 | N | ||
| A/C |
|
ybjX | N | Y | 53 | Y |
| pdgL | N | Y | 53 | N | ||
| virK | Y | Y | 55 | N | ||
| yobG | N | Y | 56 | Y | ||
| mig-14 | Y | Y | 59 | N | ||
| ssrB | Y | Y | 60 | N | ||
| B/C |
|
pagP | N | Y | 51 | Y |
| iraP (yaiB)‡ | N | Y | 53 | Y | ||
| pagD | N | Y | 58 | N | ||
Twenty-three PhoP regulon members were previously classified19 on the basis of the position and orientation of PhoP binding sites (green arrows), relative to the transcriptional start (bent arrow). Blue squares indicate the relative positions of the −10 and −35 boxes. H-NS targets (Y) and non-targets (N), as determined by transcript microarray or ChIP-chip2, are indicated in the “H-NS repression” and “H-NS binding” columns, respectively. The presence (Y) or absence (N) of a homolog in Escherichia coli K-12 is indicated in “Homolog in E. coli K-12” column. %AT indicates the AT-content of a gene's coding sequence.
ompX is adjacent to an H-NS bound gene.
E. coli does not contain pgtE but does contain a related PhoP-regulated gene (ompT).
iraP is also named yaiB.