TABLE 1.

Illustrative patterns in the Arrhenius activation parameters for ht-ADH and ps-ADH below 30 °C

From Refs. 40, 47, and 50.

ADH ortholog	ΔH‡	log(Aobs)	TΔS‡, 30 °C	KIE, 30 °C
	kcal/mol		kcal/mol
ht-ADH
WT	21.4	17	5.6	3.2
L176A	25.8	19	8.8	4.1
L176del	34.8	25	16.5	4.3
V260A	32.3	24	15.4	4.1
ps-ADH	9.2	8	−7.5	4.0a

^a At 20 °C; the comparable KIE for ht-ADH at this temperature is 5.0.