FIGURE 1.

PK analysis of oral Bex and LG. Brain and plasma levels of Bex (100 mg/kg/day) or equimolar LG (104 mg/kg/day) delivered orally to mice were measured by LC-MS/MS. A, concentrations of Bex in brain and plasma at various time points after delivery by gavage to C57BL/6 mice. B, concentrations of LG in brain and plasma at various time points after delivery by gavage to C57BL/6 mice. C, averaged concentrations of Bex and LG in brain and plasma at 1, 4, and 24 h during a 24-h delivery by hydrogel to C57BL/6 mice (for 300day plasma samples) or to E3FAD and E4FAD mice. Data are expressed as mean ± S.E. (n = 4–11).