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RXR agonists induce hepatomegaly in EFAD mice. A, correlation analysis between ABCA1 and oAβ levels in EFAD-CX. Liver weights were measured in E3FAD and E4FAD mice treated with Bex, LG, or VC by 7-day gavage (5.75–6 months) (B), 7-day hydrogel (5.75–6 months) (C), and 30-day hydrogel (5–6 months) (D). Data are expressed as the mean ± S.E. and were analyzed by one-way ANOVA followed by Tukey's multiple comparison post hoc analysis. n = 6. *, p < 0.05 versus VC.
