TABLE 1.

RXR agonist treatment protocols

Study	Age and length of treatment	Drug delivery	Treatment
T1	5.75 to 6 months	Gavage	VC, sesame oil
	(7 days)		Bex, 20 mg/ml sesame oil
			LG, 20.86 mg/ml in sesame oil
			Treatment, 5 μl/g (mouse weight)
T2	5.75 to 6 months	Hydrogel	VC, 0.4% DMSO in hydrogel
	(7 days)		Bex, 3 mg/4.5 ml in hydrogel
			LG, 3.13 mg/4.5 ml in hydrogel
			Treatment, ∼4.5 ml hydrogel consumed per mouse/day (for a 30-g mouse)
T3	5 to 6 months	Hydrogel	As above, hydrogel replaced every 2–3 days
	(30-day prevention)