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Analysis of NMO-IgG binding at pH 7 and 5.5 using AQP4 and D69H expressing cells. NMO-IgG binding, of serum from a representative NMO patient (patient 5), was tested by changing the histidine side chain from neutral (pH 7) to positive charge (pH 5.5), using AQP4 and D69H expressing cells. Panel A shows a representative result obtained at 1:4000. Panel B shows a dilution binding assay. Note that the NMO-IgG binding property is pH independent at tested pH.
