FIGURE 1.

Multiple sequence alignment of amino acid sequences of different cysteine dioxygenases and homologous enzymes from eukaryotic and prokaryotic species. The alignment was generated applying the free software BioEdit (Tom Hall, Ibis Biosciences, Carlsbad, CA). Cupin motifs 1 and 2 are highlighted in gray, strictly conserved amino acid residues among all investigated sequences are highlighted in black, and histidine residues responsible for the coordination of iron are marked by an asterisk.