Table 3.

Logistic Regression Modeling of Probability of Cushing’s Disease Based on Pathophysiological Findings, Other Variables, and the High-Dose Dexamethasone Suppression Test (HDDST)

Model no.	Variables	Sensitivity	Specificity	Diagnostic accuracy
1	Age, sex, duration, hypokalemia, urinary free cortisol, plasma ACTH, suppression by ≤50%a	100	80	96
2	Age, sex, duration, hypokalemia, urinary free cortisol, plasma ACTH, % suppressionb	98	80	94
3	Age, sex, duration, hypokalemia, urine free cortisol, plasma ACTH	98	78	93
4	Duration, hypokalemia, plasma ACTH	98	67	91
5	Suppression by ≥50%a	79	67	77
6	% Suppressionb	93	27	77

^aSuppression of cortisol after HDDST;

^bSuppression of cortisol (after HDDST) as a continuous variable.

Adapted from (16).