Table 1.
Body Weight, Kidney/Body Weight Ratio, Urinary and Blood Parameters, Blood Pressure, and Histopathological Parameters in Rats
| Parameters | Control | Aldosterone | Aldosterone/sulforaphane | Sulforaphane |
|---|---|---|---|---|
| Body weight (g) | 501±11 | 522±7 | 516±7 | 537±7 |
| Kidney/body weight ratio (‰) | 3.9±0.2 | 4.7±0.5* | 4.4±0.2 | 3.8±0.3# |
| Urine volume (ml) | 40±4 | 83±20* | 23±7# | 18±3# |
| Creatinine clearance (ml/min) | 94±10 | 58±5 | 135±18# | 105±6 |
| Glomerular sclerosis index | 0.53±0.08 | 1.05±0.16* | 0.54±0.09# | 0.46±0.11# |
| Mesangiolysis index | 0.20±0.04 | 0.44±0.07* | 0.32±0.07 | 0.24±0.05 |
| Blood pressure (mm Hg) | 153±5 | 180±7* | 158±2# | 147±3# |
| Aldosterone in plasma (nM) | 1.4±0.2 | 1.7±.0.2 | 1.6±.0.2 | 1.4±.0.2 |
| Aldosterone in urine (μg/24 h) | 0.18±0.03 | 0.41±0.09* | 0.27±0.04# | 0.15±0.02# |
For body weight, creatinine clearance, blood pressure, and aldosterone in plasma, the mean values±SEM are shown, *p≤0.05 versus the control; #p≤0.05 versus the aldosterone-treated group, tested by ANOVA with subsequent post-hoc comparisons by Scheffé. For kidney/body weight ratio, urine volume, and aldosterone in urine, the median±the standard error of the median is shown, *p≤0.05 versus the control; #p≤0.05 versus the aldosterone-treated group, evaluated by Kruskal–Wallis test with subsequent post-hoc comparisons by Dunn.