Table 1.
Associations of 9 ANTXR2 SNPs with AS in (1A) the independent replication study, (1B) HLA-B27-positive and (1C) HLA-B27-negative stratified analyses
| Replication study | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| (A) All cases vs controls (2978 vs 8365) | (B) B27+ cases vs B27+ controls (1935 vs 696) | (C) B27– cases vs B27– controls (358 vs 7669) | |||||||||
| SNP | Minor allele | MAF (%) cases/controls |
p Value | OR | 95% CI | p Value | OR | 95% CI | p Value | OR | 95% CI |
| rs6534639 | C | 45/47 | 0.0005* | 0.90 | 0.85 to 0.95 | 0.09 | 0.90 | 0.79 to 1.02 | 0.01* | 0.83 | 0.71 to 0.96 |
| rs4234848 | G | 31/32 | 0.08 | 0.94 | 0.88 to 1.01 | 0.37 | 0.94 | 0.82 to 1.08 | 0.1 | 0.88 | 0.74 to 1.04 |
| rs11098965 | C | 24/25 | 0.2 | 0.96 | 0.89 to 1.03 | 0.19 | 0.91 | 0.79 to 1.05 | 0.4 | 0.93 | 0.78 to 1.11 |
| rs4444771 | G | 24/25 | 0.2 | 0.95 | 0.89 to 1.02 | 0.14 | 0.90 | 0.78 to 1.03 | 0.6 | 0.96 | 0.80 to 1.14 |
| rs12504282 | C | 43/46 | 0.0001* | 0.89 | 0.84 to 0.94 | 0.006* | 0.84 | 0.74 to 0.95 | 0.4 | 0.93 | 0.80 to 1.08 |
| rs10000471 | C | 33/35 | 0.01* | 0.92 | 0.86 to 0.98 | 0.03* | 0.87 | 0.76 to 0.99 | 0.1 | 0.88 | 0.75 to 1.04 |
| rs4640621 | A | 34/36 | 0.001* | 0.90 | 0.85 to 0.96 | 0.01* | 0.85 | 0.75 to 0.97 | 1.0 | 1.00 | 0.85 to 1.17 |
| rs4333130 | G | 34/36 | 0.002* | 0.91 | 0.85 to 0.97 | 0.02* | 0.86 | 0.75 to 0.98 | 1.0 | 1.00 | 0.85 to 1.17 |
| rs6839672 | A | 16/15 | 0.6 | 1.02 | 0.94 to 1.11 | 0.10 | 1.16 | 0.97 to 1.38 | 0.3 | 0.90 | 0.72 to 1.12 |
Nominally significant (p<0.05) associations are shown (*).
Number of cases and controls in each analysis is also shown in brackets. (B27: HLA-B27).
HLA, human leukocyte antigen; MAF, minor allele frequency; SNP, single nucleotide polymorphism.