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EGFR/gab1 but not c-Src are signaling elements upstream of PI3K/Akt for mediating the effects of H2S. (A, B) NaHS-induced Akt (A) and PI3K (B) phosphorylation was abrogated by siRNAs knockdown of gab1 and EGFR but not c-Src. (C) NaHS-induced gab1 phosphorylation was abrogated by siRNA knockdown of EGFR but not c-Src. (D–F) The siRNA knockdown of c-Src had no effect on the phosphorylation of EGFR Tyr1068 (D), Tyr1086 (E), or Tyr845 (F). Data in the graphs are means±SEM.
